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Actin assembly-inducing protein : ウィキペディア英語版 | Actin assembly-inducing protein
The Actin assembly-inducing protein (ActA) is a protein encoded and used by ''Listeria monocytogenes'' to propel itself through a mammalian host cell. ActA is a bacterial surface protein comprising a membrane-spanning region. In a mammalian cell the bacterial ActA interacts with the Arp2/3 complex and actin monomers to induce actin polymerization on the bacterial surface generating an actin comet tail. The gene encoding ActA is named ''actA'' or prtB.〔(Uniprot P33379 )〕 == Introduction == As soon as ''L. monocytogenes'' bacteria are ingested by humans, they get internalized into intestinal epithelium cells and rapidly try to escape their internalization vacuole. In the cytosol they start to polymerize actin on their surface by the help of the ActA protein. It has been shown that ActA is not only necessary but also sufficient to induce motility of bacteria in the absence of other bacterial factors.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Actin assembly-inducing protein」の詳細全文を読む
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